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40 Nevertheless, accumulating evidence indicates that CR is detrimental to skeletal metabolism, as evidenced by reductions in BMD and bone mineral content (BMC), diminished bone formation indices (e.g., bone formation rate, osteoblast number), and a concomitant increase in bone resorption
1 As the result on cardiovascular death was not statistically significant over the length of the trial, the remaining secondary confirmatory endpoints were not tested for superiority due to hierarchical testing
doi: 10.2147/DMSO.S387116 177 GibbonsCBlundellJTetens HoffSDahlKBauerRBkdalT
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